The network revealed on Wednesday that starting on September 12, "Days of Our Lives" will only be accessible via the Peacock streaming service.
Following the transition, new episodes will continue to air on Peacock every weekday.
The show debuted on November 8, 1965, and over its run, it has garnered 58 Emmy Awards. The 14,000th instalment of "Days of Our Lives" aired on NBC in 2020.
In addition to the daily episodes, the show already has a home on Peacock.
Currently, Peacock Premium costs $4.99 per month for a subscription; Peacock Premium Plus, which is ad-free, costs $9.99.
Thousands of television and movie hours, exclusive Peacock streaming channels, and live sporting events are all included in the membership.
Peacock is accessible on a variety of platforms, including smart TVs, Roku, Apple TV, Android TV, and Xfinity.
The hour-long, daily programme "NBC News Daily" will fill the afternoon TV void left by "Days" moving.